SYLLABUS
CHEM 210 Organic Chemistry Survey (3+3P) 4 credits
Catalog Description
A one semester survey for students requiring a brief coverage of important classes of organic compounds and their application to biology. Coverage includes nomenclature, preparation, chemical transformation of functional groups, reaction mechanisms, carbohydrates, proteins, DNA, and metabolic reactions. Prerequisite: CHEM 110. Semester Offered-On Demand.
General Objectives: Upon completion of the course, the student should have a working knowledge of the following:
1. 3D visualization: hybridization, orbital overlap, resonance, and molecular structure.
2. nomenclature, properties, and reactions of alkanes, alkenes, and alkynes.
3. nomenclature, properties, and reactions of aromatics.
4. stereochemistry
5. nomenclature, properties, and reactions of alcohols, ethers, aldehydes, ketones, and carboxyllic acid derivatives.
6. nomenclature, properties, and reactions of amines.
7. nomenclature, properties, and reactions of coarbohydrates, amino acids, peptides, proteins, lipds, and nucleic acids.
8. organic chemistry of metabolic pathways.
9. laboratory synthesis: techniques, gas chromatography; infra red, mass, and nuclear magnetic resonance spectroscopies.
Specific Objectives: At the end of this course the student will be able to:
1.1 Draw resonance structures and use them to predict stabilities of radicals and ions.
1.2 Identify nucleophiles and electrophiles, and predict Lewis acid-base reactions.
1.3 Predict hybridization and geometry of atoms in molecules.
1.4 Describe sigma and pi bonding in terms of orbital overlap.
1.5 Determine the polarity of bonds and molecules based on 3 D structure.
2.1 Name and draw simple alkanes, alkenes, and alkynes
2.2 Compare the energies of alkane conformations and predict the most stable conformations.
2.3 Predict the products and explain the mechanism of the free-radical halogenation of alkanes.
2.4 Predict the products and explain the mechanism of addition reactions of alkenes and alkynes.
2.5 Predict the products and explain the mechanism of elimination reactions to form alkenes and alkynes.
3.1 Name and draw simple aromatic compounds.
3.2 Define aromatic.
3.3 Predict the products and explain the mechanism of electrophillic aromatic substitution.
3.4 Predict the products and explain the mechanism of Friedel-Crafts Alkylation and Acylation.
4.1 Predict the products of SN1, SN2, E1, and E2 reactions including stereochemistry.
4.2 Classify molecules as chiral or achiral, and identify mirror planes of symmetry.
4.3 Identify enantiomers, diastereomers, and meso compounds.
5.1 Name and draw simple alcohols, ethers, aldehydes, ketones, and carboxyllic acids
5.2 Describe how alcohols, ethers, aldehydes, ketones, and carboxyllic acids are synthesized.
5.3 Show the mechanism of the ring opening of epoxides.
5.4 Predict the products and show the mechanism of nucleophilic additions to carbonyls.
5.5 Predict the products and show the mechanism for nucleophilic acyl substitution.
5.6 Describe Keto-Enol Tautomerism.
5.7 Predict the producs and exlplain the mechanism of carbonyl condensation reactions.
6.1 Name and draw simple amines.
6.2 Describe the synthesis and reactions of amines.
6.3 Identify and describe heterocylcic amines.
7.1 Describe the configuration of monosaccharides and aldoses using Fisher Projections.
7.2 Show the mechanism of hemiacetal formation.
7.3 Describe the structure of disaccharides and polysaccharides.
7.4 Discuss carbohydrates in nature.
7.5 Name and draw amino acids and peptides, and polypeptides.
7.6 Determine peptide structure from amino acid analysis.
7.7 Show how peptides can be synthesized.
7.8 Define levels of protein structure.
7.9 Identify lipids and nucleic acids
7.10 Describe the structure of DNA
7.11 Describe and define transcription and translation.
8.1 Describe metabolism and biochemical energy.
8.2 Define and describe beta-oxidation pathway, glycolysis, the citric acid cycle, and transamination.
9.1 Synthesize and investigate organic reactions in the laboratory.
9.2 Apply chemical and physical tests to identify organic compounds.
9.3 Identify key components and principles of operation of a gas chromatograph.
9.4 Use gas chromatography to separate and identify components of a mixture.
9.5 Describe how an infrared spectrophotometer works.
9.6 Given an IR spectrum, idententify functional groups.
9.7 Describe how a mass spectrometer works.
9.8 Use the fragmentation pattern of a mass spectrum to determine structure.
9.9 Describe how a nuclear magnetic resonanance spectrometer works.
9.10 Combine the chemical shifts, intergrals, and spin-spin splitting patterns in the NMR spectrum with information from IR and MS to determine the structures of organic compounds.
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